On February 4, 2007, the Colts won Super Bowl XLI, defeating the Chicago Bears 29-17 in Dolphin Stadium, in Miami Gardens, Florida in the first ever Super Bowl played in the rain. Rain played a substantial obstacle to both teams, as a combined total of six turnovers were recorded in the first half, a new Super Bowl high. Quarterback Peyton Manning, after a rocky start which saw him throw an interception, was named the MVP when he recovered to complete 25 of 38 passes, one for a touchdown. Reggie Wayne was the sole receiver of a passing touchdown from the Colts offense, and the running back duo of Dominic Rhodes and Joseph Addai combined for 190 yards, with Rhodes achieving the only rushing touchdown, and kicker Adam Vinatieri converted on 3 out of 4 field goal attempts. On the defensive side of the ball Pro Bowl safety Bob Sanders and cornerback Kelvin Hayden both intercepted Bears' quarterback Rex Grossman towards the end of the game, with Hayden returning his for 56 yards for a touchdown which helped seal the win for the Colts.

In winning the game Indianapolis became the first "dome team" to win a Super Bowl in an outdoor stadium. Tony Dungy also became only the third man to have won the Super Bowl as both a head coach and a player (along with Tom Flores and Mike Ditka). Tony was also the first African-American head coach to win a Super Bowl.